About the Paradise® Ultrasound Renal Denervation System

The Paradise® Ultrasound Renal Denervation system is the first-ever minimally invasive procedure to reduce uncontrolled or resistant hypertension with ultrasound. It can be used alongside other ways to reduce high blood pressure:

Graphic source: About Hypertension - Recor Medical

It reduces overactivity in the nerves that lead to the kidneys to help lower blood pressure. Lowering blood pressure has been shown to reduce the risk of life-threatening chronic conditions, including¹:

• Heart attack
• Stroke
• Chronic renal failure
• Cognitive decline

What is renal denervation?

Blood pressure in your body is partly regulated by messages from your brain, heart and kidneys. When these nerves are overactive, you might have increased blood pressure. Renal denervation reduces activity in your renal nerves using ultrasound to help lower your blood pressure.

Renal denervation can help reduce your blood pressure when lifestyle changes and blood pressure medications are not enough to adequately control hypertension.

How the Paradise® Ultrasound Renal Denervation System Works

Anesthesia helps keep you comfortable during this procedure that lasts about an hour. An interventional cardiologist makes a small incision in your groin and inserts a catheter into your femoral artery. The cardiologist then guides the Paradise system’s catheter to the renal arteries, which are the blood vessels that lead to your kidneys.

The Paradise catheter delivers a 360-degree ring of ultrasound energy to the nerves around your renal arteries. The ultrasound energy waves help calm the renal nerves, which has been shown to reduce blood pressure.^2-5

Each delivery of ultrasound energy is just seven seconds, with only 2-3 treatments needed per main renal artery. The unique HydroCooling system helps protect the arteries during treatment by circulating sterile water through the Paradise system’s balloon catheter.

Benefits

Renal denervation offers another treatment option for patients with chronically high blood pressure that is not well-controlled by lifestyle changes or medication. The procedure delivers lasting treatment for uncontrolled or resistant hypertension and has been proven safe and effective across several clinical trials.^2-5 The one-time procedure is minimally invasive, requiring one small incision, and nothing is left in the body after treatment. An overnight stay may be needed, but many patients are able to go home the same day.

Risks

Experienced doctors at Willis Knighton perform renal denervation safely with a low risk of complications. The most common adverse effects in clinical studies include pain, vascular access site complications and vasospasm.

1. Ettehad D, et al. The Lancet. 2016;387:957-67.
2. Azizi M. JAMA. 2023;329(8):651-661
3. Azizi M. et al. Lancet. 2018 Jun 9;391(10137):2335-2345.
4. Azizi M. et al. Lancet. 2021 Jun 26;397(10293):2476-2486.
5. Kirtane A. et al. JAMA Cardiol. 2023;8(5):464-473